HIV Neuropathogenesis: a Tight Rope Walk of Innate Immunity
نویسندگان
چکیده
منابع مشابه
Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection.
Human immunodeficiency virus type 1 (HIV-1)-associated dementia is a neuroinflammatory brain disorder that is fueled by viral infection and immune activation of brain mononuclear phagocytes (MP; macrophages and microglia). MP serve as a reservoir for persistent viral infection, a vehicle for viral dissemination throughout the brain, and a major source of neurotoxic products that when produced i...
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متن کاملThe neuropathogenesis of HIV-1 infection.
HIV encephalitis is the common pathologic correlate of HIV-dementia (HAD). HIV-infected brain mononuclear phagocytes (MP) (macrophages and microglia) are reservoirs for persistent viral infection. When activated, MP contribute to neuronal damage. Such activated and virus-infected macrophages secrete cellular and viral factors, triggering neural destructive immune responses. Our Center's laborat...
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ژورنال
عنوان ژورنال: Journal of Neuroimmune Pharmacology
سال: 2010
ISSN: 1557-1890,1557-1904
DOI: 10.1007/s11481-010-9211-1